Direct evaluation of cellular internalization rates using chromogenic disulfides.

Evaluation of DNA damage in a Her2+ cell line induced by an Auger-emitting immunoconjugate

Introduction: Auger electron based radioimmunotherapy (RIT) using 111In-DOTA-trastuzumab (111In-DOTA-antiHer2) feasibility was studied in vitro on a HER2/neu positive cell line, SkBr3. Methods:111In-DOTA-antiHer2 was prepared according to the optimized conditions followed by quality control tests including radioch...

Prediction of Body Image Dissatisfaction from Self-esteem, Thin-ideal Internalization and Appearance-related Social Comparison

Introduction: The present study has aimed to demonstrate the relationship between body image dissatisfaction and three variables of self-esteem as a psychological factor along with thin-ideal internalization and appearance-related social comparison as psychosocial factors. Methods: To conduct this study, 477 Tehran high-school students were recruited by a...

Convenient method for the synthesis of symmetrical disulfides using 1-butyl- 3-methylimidazolium hydroxide in water

Preparation and evaluation of 67Ga-DOTA-Bombesin (7-14) as a tumor scintigraphic agent

  Introduction: Bombesin is a 14-aminoacid peptide isolated from frog skin. The mammalian counterparts of the frog peptide are neuromedin B (NMB) and gastrin-releasing peptide (GRP). Bombesin (BBN) is a peptide showing high affinity for the gastrin releasing peptide receptor (GRPr). Prostate, small cell lung cancer, breast, gastric, and colon cancers are known to over...

In vitro investigations of smart drug delivery systems based on redox-sensitive cross-linked micelles.

Redox-sensitive micelles are designed by using block copolymers of different architectures composed of a hydrophilic block of poly(ethylene oxide), and hydrophobic blocks of poly(ϵ-caprolactone) and poly(α-azide-ϵ-caprolactone). Stability of these micelles is insured in diluted media by cross-linking their core via the addition of a bifunctional cross-linker, while redox sensitivity is provided...